Misestimation of heritability and prediction accuracy of male-pattern baldness
نویسندگان
چکیده
منابع مشابه
Genetic prediction of male pattern baldness
Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x...
متن کاملGenetic basis of male pattern baldness.
Common pattern baldness (androgenetic alopecia) is the most common form of hair loss in humans. In Caucasians, normal male hair loss, commonly known as ‘‘male pattern baldness’’ (MPB; MIM 109200), is noticeable in about 20% of men aged 20, and increases steadily with age, so that a male in his 90s has a 90% chance of having some degree of MPB. In addition to being among the most common natural ...
متن کاملSurgical treatment of male pattern baldness.
1 Chandler JR. Malignant otitis externa. Laryngoscope 1968;78:1257-94. 2 Chandler JR. Pathogenesis and treatment of facial paralysis due to malignant otitis externa. Ann OtolRhinol Laryngol 1972;81:648-58. 3 SchwartzGA, BlumenkrantzMJ, StudmakerWHL. Neurologiccomplicationsofmalignantotitis extema. Neuroloz 1971;21:1077-84. 4 Joachims HZ. Malignant external otitis in children. Arch Otola,yngol 1...
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The aim of this study was to determine the effect of marker density, level of heritability, number of QTLs, and size of training set on the genomic accuracy over three generations. Thereby, a trait was simulated with heritability of 0.10, 0.25 or 0.40. For each animal, a genome with 20 chromosomes, 1 Morgan each, was simulated. Different marker densities (2000, 4000 and 6000 markers) and 400 an...
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هدف اصلی این تحقیق بررسی تاثیر برنامه ریزی زمانی، هم چنین افزایش میزان پیچیدگی تکالیف در نظر گرفته شده بصورت همزمان، بر دقت و صحت و پیچیدگی عملکرد نوشتاری زبان آموزان می باشد. بدین منظور، 50 نفر از دانش آموزان دختر در رده ی سنی 16 الی 18 سال به عنوان شرکت کنندگان در این زمینه ی تحقیق در نظر گرفته شدند و به دو گروه آزمایشی و کنترل بصورت اتفاقی تقسیم شدند. اعضای گروه آزمایشی هر دو تکلیف ساده و پی...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04807-3